(I will not drone on about the silliness of design that extends beyond viewable space – just don't do it.)
Since time began, humans have been observing the natural patterns around us. Over time, we have become instinctively comfortable with the familiar sights of nature. You can use this instinct to your advantage and make your layouts feel more friendly and usable by modeling patterns from the nature world.
Arrangements can be modeled after spirals, waterfalls, circles, cascades, steps, slopes, or an endless number of possibilities. The hardest part is deciding which arrangement is best for your content. (It is decidedly harder to fit you content into a certain layout than the other way around. I think this is why so many people look down on templates.) Remember, most things in nature are not symmetrical, even numbered, or perfectly matched.